Cardiac Sympathetic Nerve Plasticity and Heart Failure
نویسندگان
چکیده
منابع مشابه
Spironolactone improves cardiac sympathetic nerve activity and symptoms in patients with congestive heart failure.
UNLABELLED We evaluated whether spironolactone would improve cardiac sympathetic nerve activity and symptoms in patients with congestive heart failure (CHF). METHODS Thirty patients with CHF (left ventricular ejection fraction [LVEF] < 40%; mean, 30% +/- 9%) were treated with an angiotensin-converting enzyme inhibitor, a loop diuretic, and, in most cases, digoxin. Fifteen patients (group A) w...
متن کاملReduction of the Cardiac Response to Postganglionic Sympathetic Nerve Stimulation in Experimental Heart Failure
The functional significance of the reduction of the heart's norepinephrine stores which occurs in experimental heart failure was studied. The responses to right and left cardio-accelerator nerve stimulation were studied in normal dogs and in dogs with chronic congestive failure and reduced myocardial norepinephrine stores. Both the chronotropic and inotropic responses to nerve stimulation were ...
متن کاملRole of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failure.
Heart failure (HF) is associated with increased sympathetic nerve activity to the heart (CSNA), which is directly linked to mortality in HF patients. Previous studies indicate that HF is associated with high levels of plasma endothelin-1 (ET-1), which correlates with the severity of the disease. We hypothesized that blockade of endothelin receptors would decrease CSNA. The effects of intravenou...
متن کاملResponse of cardiac sympathetic nerve activity to intravenous irbesartan in heart failure.
To determine the effect of irbesartan treatment on resting levels and arterial baroreflex control of cardiac sympathetic nerve activity (CSNA) in heart failure (HF), we studied conscious normal sheep and sheep with HF induced by rapid ventricular pacing for 8-10 wk (n = 7 per group). In HF, there is a large increase in CSNA that is detrimental to outcome. The causes of this increase in CSNA and...
متن کاملBasis for the preferential activation of cardiac sympathetic nerve activity in heart failure.
In heart failure (HF), sympathetic nerve activity is increased. Measurements in HF patients of cardiac norepinephrine spillover, reflecting cardiac sympathetic nerve activity (CSNA), indicate that it is increased earlier and to a greater extent than sympathetic activity to other organs. This has important consequences because it worsens prognosis, provoking arrhythmias and sudden death. To eluc...
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ژورنال
عنوان ژورنال: Journal of Pain & Relief
سال: 2015
ISSN: 2167-0846
DOI: 10.4172/2167-0846.1000223